IMMUNOGENETICS: A paradigm for Bio-information at the cutting edge of Biology

Since its discovery in the early fifties, the Major Histocompatibility complex (MHC) has been at the very forefront of Biology research with a specific contribution to genetic research and immunology. It concentrates about 1% of the genes in 1‰ of the DNA sequences, most of them being involved in protection against pathogens and definition of the immunological self identity. Understanding the nature and functional consequences of genetic variation involving the genes encoding immunological proteins the MHC region or outside the MHC region has always highlighted future directions for bio-information research.

France has a long tradition of Immunogenetics excellence. In 1980, as a tribute to MHC importance in the explosion of biological information for health, Pr Jean Dausset received the Nobel Prize of medicine. As a consequence of its genomic structure and its genetic diversity, the MHC has been considered as a paradigm region for –omics era of biology. MHC and more recently an other Immunogenetic region of the human genome the KIR gene cluster are model regions remain the most studied regions for the sake of transplantation outcome and disease susceptibility establishing fundamental concepts of linkage disequilibrium, haplotype structure, meiotic recombination, human population diversification. Extensive efforts of sequencing are generally pioneering in Immunogenetics.

MHC continues to address insightful issues and remains in the vanguard of contemporary needs for evolving concepts and tools in human genomics.

In this collaborative project supervised Dr. P.A. Gourraud (Methodomics, UCSF), we present an haplotype frequencies estimation software that has been developped for Human Leukocyte Antigens (HLA) and Killer Immunoglobulin Receptor (KIR) polymorphism.  (EstiHaplo software: download here)



Pierre-Antoine Gourraud, Ashely Meenagh, Jean-Yves Trosset, Vanessa Proux, Jorge Oksenberg, Derek Middleton. Haplotype estimation using kir genotypes from familial and/or unrelated individual genotype data. 24th European Immunogenetics and Histocompatibility Conference (EFI) and 17th Annual Meeting of the Italian Society for Immunogenetics and Transplantation (AIBT).

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Jean-Yves Trosset